Head of Clinical Investigations and Trials Operations
Medicines and Healthcare products Regulatory Agency (MHRA)
London , United Kingdom
Following several years of postdoctoral research, Crina Cacou has spent over two decades at the Medicines and Healthcare products Regulatory Agency (MHRA). Crina began in the Medical Devices Directorate as a Specialist overseeing complex investigations, before progressing to roles such as Clinical Investigations Manager and Team Manager. Crina also served as a Policy Manager at the UK Department of Health and Social Care. Currently, Crina is part of the Clinical Investigations and Trials team, where her responsibilities include updating and implementing the Medicines for Human Use (Clinical Trials) (Amendment) Regulations 2025 in addition to other key initiatives.
Recent publications:
• Manfrin A. et al. (2025) Evaluation of the MHRA’s introduction of a risk-proportionate approach for clinical trials: an analysis of 4617 applications assessed between September 2023 and August 2024. British Journal of Clinical Pharmacology. DOI: 10.1002/bcp.70308.
• Messer J. et al. (2025) UK Clinical Research Regulation: A Collaborative Path to Modernization, Innovation, and Access. https://globalforum.diaglobal.org/issue/september-2025/uk-clinical-research-regulation-a-collaborative-path-to-modernization-innovation-and-access/
• Lee K et al. (2025) The Evolution of Digital Transformation to Support the UK Clinical Trials Regulation https://globalforum.diaglobal.org/issue/september-2025/the-evolution-of-digital-transformation-to-support-the-uk-clinical-trials-regulation/
EU CTR, UK CTA Reform, and ICH E6(R3): Strategies for Clinical Trial Success in the EU and UK
Thursday, May 7, 2026
14:30 - 15:30 WEST